Kontakt X:X | DOI: 10.32725/kont.2025.030

Tissue adhesives in the prevention of phlebitis and migration of PICC catheters in adults: a randomized prospective study

Iveta Constantine1, *, Magda Michaliková1, Andrea Polanská1, Zuzana Figurová1, Adéla Kondé2
1 University Hospital Ostrava, Ostrava, Czech Republic
2 University of Ostrava, Faculty of Medicine, Ostrava, Czech Republic

Aim: Tissue adhesives (TA) have been reported to improve the stability of various types of catheters. TA use for peripherally inserted central venous catheters (PICCs), however, remains largely unstudied. Here, we aimed to evaluate the effects of TA use on the development of phlebitis, bacterial colonization, and catheter migration in PICCs inserted in adult patients.

Methods: This prospective randomized trial was conducted over a 43-month period from May 2021 to December 2024. Patients were divided into treatment group (PICC secured with TA) and control group (no TA). Signs of phlebitis (evaluated using CLISA scale) and catheter migration were recorded on Days 1 and 7. Swabs for determining bacterial colonization were taken on Day 7.

Results: Of 253 patients included in the final evaluation, none developed phlebitis, although bacterial colonization was detected in 30 patients in the control group and 26 in the TA group on Day 7. Of these, however, only 4 samples contained potentially pathogenic bacteria. Migration >20 mm occurred in < 5% of patients in both groups, minor migration < 20 mm in < 10% of patients in each group. No statistically significant differences were detected between the groups in any of the observed parameters.

Conclusion: In a setting with highly trained nursing staff using an anchoring device and dressing, the additional use of TA brought no benefits to the patients.

Keywords: External length; Migration; Phlebitis; PICC; Tissue adhesive
Grants and funding:

This work was supported by the Ministry of Health, Czech Republic - conceptual development of research organization (FNOs/2021).

Conflicts of interest:

The authors have no competing interests to declare.

Received: February 13, 2025; Revised: April 30, 2025; Accepted: June 26, 2025; Prepublished online: June 26, 2025 

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