Kontakt 2007, 9(1):168-171 | DOI: 10.32725/kont.2007.023

Effects of nutrition on the origination of diabetes in childrenBiomedicine

Zdeňka Tomšíková^*, česká pracovní skupina studie TRIGR

Nemocnice České Budějovice, a. s, neonatologické oddělení

The incidence of the first type diabetes is ever increasing during the recent years. First type diabetes mellitus (DM) is currently the second most frequent chronic children disease in developed countries. The research in the field of diabetes demonstrated in recent years that nutrition can affect the risk of the diabetes origination in children. In experimental studies on animals, predisposing effects of the presence of cow milk proteins in the food for the diabetes development was demonstrated. A number of scientists believe that the early load of the immunity system with cow milk proteins present in the nutrition of infants can trigger and/or amplify the autoimmunity reaction leading to the destruction of beta cells in the pancreas producing insulin, but there are also demonstrations that do not support this opinion. Thus, an extensive international prospective interventional study TRIGR (Trial to Reduce IDDM in the Genetically at Risk) was started.
The basic research problem of this project is whether the total elimination of cow milk proteins from the food in the course of the first six months of the life can reduce the extent of the origination of auto-antibodies associated with the disease and/or clinical manifestations of first type diabetes in children at a higher genetic risk of its origination.
Newborns are being included into the TRIGR, whose biological mother, father or consanguineous brother or sister has first type DM.
The recruitment of children into the study was started in May 2002 and terminated by the last day of 2006. Total of 5156 newborns (in the Czech Republic 410) are included worldwide into the study; of them 2161 (in the Czech Republic 164) of children with a suitable (risk) genotype.

Keywords: Diabetes mellitus; insulin; prevention

Received: April 9, 2007; Accepted: April 27, 2007; Published: June 15, 2007  Show citation