Kontakt 2009, 11(2):459-464 | DOI: 10.32725/kont.2009.069

Pathogenesis of ulcus crurisBiomedicine

Jozef Beláček¹, Ján Jakubovský², Eliška Kubíková³, Olia Elhassoun², Jozef Novotný^4,*

¹ Fakultná nemocnica, pracovisko Nemocnica akademika Dérera, chirurgická klinika, Bratislava, SR

² Univerzita Komenského, Lekárska fakulta, Ústav patologickej anatómie, Bratislava, SR

³ Univerzita Komenského, Lekárska fakulta, Anatomický ústav, Bratislava, SR

⁴ Jihočeská univerzita v Českých Budějovicích, Zdravotně sociální fakulta, ČR

Citizens of the consumption society suffer from a lack of movement activities, have bad nutritional habits and other problems. Ulcus cruris also belong to consequences of the bad style of life. It is of a considerable interest to clinical as well as academic specialists. The disease of a complex nature forms a considerable civilization load to the population. By its risk nature, it deteriorates the quality of life of the person involved. Ulcus cruris presents a serious sociological-economic problem particularly involving inhabitants of economically advanced countries. This severity is based on the chronic course of the disease and also tediousness of the treatment. The worst type of chronic insufficiency of veins makes about 57 - 80% of causes of all the long-healing wounds. Ulcers on arterial basis account for 4 - 30% and mixed arterial-venous ulcers for about 10 - 15%. The latter ones occur in 6 - 19% of cases. The main cause is stagnation of the blood in veins of the limb involved, rarely disorders of the arterial flow. Thus, ulcus cruris venosum is considered as the third stage of the chronic stagnation of the blood in veins. Common forms of blood flow disorders include chronic compartment syndrome, which is concealed under circulation disorders. Thus, it should be detected as soon as possible with the aim to prevent further damage to the tissue. It is also a cause of considerable complications of cardiovascular diseases. Poor regimen as well as diseased style of life, in addition to other risk factors, bring a vicious circle for the involved person as well as for his/her surroundings. Thus, they are all-society problems playing a considerable role according to the World Health Organization in their document Health 21. The progress in solving the problems of ulcus cruris in further years particularly brings widened knowledge about intercellular relationships, intercellular mass and mediators implementing these relationships. This knowledge can considerably contribute to the treatment of the persons involved. In the work presented here, we are pointing out the fact that improved theoretical knowledge will bring contributions to diagnostics, therapy and mainly prevention of this severe disease.

Keywords: Ulcus Cruris; microcirculation; etiology; pathogenesis; mediators; intercellular relationships

Received: October 5, 2009; Accepted: October 19, 2009; Published: December 18, 2009  Show citation