Kontakt 2010, 12(1):105-111 | DOI: 10.32725/kont.2010.013

Epidemiology of tuberculosis - reaction to BCG vaccineBiomedicine

Pavel Fošum1,*, Vladimír Príkazský2
1 Jihočeská univerzita v Českých Budějovicích, Zdravotně sociální fakulta, katedra veřejného a sociálního zdravotnictví
2 Státní zdravotní ústav, Praha

Based on skeletal demonstrations, the Mycobacterium tuberculosis occurred as soon as in the Neolith. According to the statistics by the World Health Organization, nine million people gets tuberculosis every year worldwide and above three million people die due to this disease annually. The purpose of the work was to describe the rate of the vaccination, time and occurrence of reactions after the vaccination with Bacile Calmette Gérin [BCG] vaccine on first days of the life. We established three hypotheses: H1 - The occurrence of undesirable effects after the BCG vaccine is rather frequent; H2 - The side effects after the BCG vaccination and further risk factors are related to deviations from the vaccination calendar; H3 - The most frequent reason for postponing subsequent vaccination according to the vaccination calendar after the BCG vaccination is non-healed scar.
We employed a quantitative research by the form of an epidemiological descriptive study with the technique of data accumulation and analysis. The data were acquired from general practitioners for children and youth. They were entered into the EpiData-Entry programme. The data processing was carried out in the EpiData Analysis programme.
The research domain consisted of a sample group including children born in 2004, 2005 and 2006 - total of 1941 children. We choose a sample group of 804 children (410 boys and 393 girls). Non-healed reaction after the BCG vaccination occurred in 307 children (38.18% from the sample group), the total number of reactions being of 439. The most frequent complication in the occurring undesirable reactions was non-healed scar - 62.4%. Children without side and undesirable reactions after the BCG vaccination received the first dose of DTPHibHB (diphtheria, tetanus, pertussis, haemophilic type B infections and viral hepatitis B) in the 14th week in average (median age 13 weeks) after the birth. Children with side and undesirable reactions after the BCG vaccination received their first dose in average in the 20th week (median age of 18 weeks) after the birth. In children with a reaction after the BCG vaccination, the first vaccination dose according to the vaccination calendar was postponed on average by 6.1 weeks. This postponing is statistically significant (p

Keywords: BCG vaccine; Mycobacterium tuberculosis; tuberculin reaction; tuberculosis; vaccine

Published: March 31, 2010  Show citation

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Fošum P, Príkazský V. Epidemiology of tuberculosis - reaction to BCG vaccine. Kontakt. 2010;12(1):105-111. doi: 10.32725/kont.2010.013.
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