Kontakt 2006, 8(1):133-140 | DOI: 10.32725/kont.2006.022

Late complication after treatment of seminomaBiomedicine

Hana Šiffnerová^1,2,*, Dana Králová³

¹ Onkologické oddělení Nemocnice České Budějovice, a.s.

² Jihočeská univerzita České Budějovice, Zdravotně sociální fakulta, katedra radiologie a toxikologie

³ Masarykova univerzita Brno, Lékařská fakulta, Centrum biostatistiky a analýz

The work is aimed at the occurrence of secondary malignities (duplicities) after the treatment for primary carcinoma of testes. The target of the work was to determine the number of secondary tumours, their effects on total survival and furthermore to compare relative risks of the origination of secondary tumours depending on particular treatment modalities.
The group comprises 313 patients with carcinoma of testes, who were subjected to surgery in 1968 - 1998 with subsequent treatment by irradiation, chemotherapy or with the use of both modalities. Statistical methods included the assessment of relative risks (RR), Fisher test or c2-test, log-rank test and survival analyses according to Kaplan-Meier.
Total of 22 secondary tumours, i.e. 7%, were found. The relative risk of the origination of duplicity in this group was low, 1.044. The median time up to the origination of secondary tumour was of 143 months. The median symptomless survival and total survival decreased from 271 months to 187.3 and 199.8 months, respectively.
Two hundred and thirteen patients experienced radiotherapy, which was associated with enhanced risk of the origination of secondary tumours (RR = 8.38). In contrast, in 100 patients subjected to chemotherapy, there was a low risk (RR = 0.38).
Patients with carcinoma of testes have mostly a long-term prognosis and thus, it is necessary to take into account secondary malignities and to include them into making decisions about the treatment and further dispensarization.

Keywords: Carcinomas of testes; undesirable treatment effects; secondary malignities

Published: May 26, 2006  Show citation